Thank you very much once again, StevenO. What you're saying is just what I was hoping to hear. If it's like a thin(nish) barrier like that you desciribed, then it both prevents easy access to (and from) the western Unknown Regions, and doesn't impede movement that stays inside that region.
I'm writing an adventure, the premise of which is loosely based on the novel "Around the World in 80 Days" (and also a bit from the French comic book "Asterix and Cleopatra"). There's a bet, and there will be a race between two parties to see who can blaze a route to an inhabited world in the Unknown Regions, with sentient inhabitants, and come back faster. Now I'm not sure how commercially viable that kind of route might be in the future, as it has to go through the tangle, thus being potentially dangerous... but with an excellent astrogator and a tempting market in the destination world, it just might be. Anyway, the plot is more about personal honor and proving a point than the actual usefulness of the resulting route.